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Interstitial keratitis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

It is a nonsuppurative inflammation of the corneal stroma (1).

Interstitial keratitis is one of the late stigmas of congenital syphilis, although milder forms occasionally occur in acquired syphilis, tuberculosis and leprosy (1).

May occur at any stage of syphilis (2)

Also associated with herpes, Cogan syndrome, parasitic and autoimmune diseases(1).

Treatment is palliative until the disease has run its course:

  • corticosteroids reduce the intensity of oedema and vascularisation
  • atropine is used to treat any accompanying iritis to prevent posterior synechiae
  • anti-syphilitic therapy is often given as a prophylactic against gummatous lesions.

Reference:

  1. Kiss S et al. Ocular manifestations and treatment of syphilis. Semin Ophthalmol. 2005 Jul-Sep;20(3):161-7.
  2. http://www.emedicine.com/OPH/topic101.htm

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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