This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Hexokinase

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Hexokinase converts:

  • glucose to glucose-6-phosphate
  • fructose to fructose-6-phosphate

To do this, it requires the energy released by the conversion of one molecule of ATP to ADP.

Hexokinase is the first enzyme in the pathways of glycolysis, glycogenesis and the pentose phosphate pathway in non-hepatic tissue. In the liver, glucokinase carries out the same reaction.

As hexokinase is unsaturated, the route taken is dependent on the balance of activity of flux-generating enzymes of each pathway in a given cell.

Glucose-6-phosphate acts by negative feedback to inhibit hexokinase.

The formation of glucose-6-phosphate or fructose-6-phosphate also traps blood-derived glucose or fructose within the cell; they are incapable of transmembranous diffusion.


Related pages

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.