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Other causes

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Abnormal utilisation:

  • drugs:
    • anticonvulsants e.g. phenytoin and barbiturates
    • barbiturates
    • dihydrofolate reductase inhibitors e.g. methotrexate and trimethoprim
    • very rarely, oral contraceptive pill

  • enzyme deficiency states:
    • methylenetetrahydrofolate reductase deficiency

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