reduced transfer with normal ventilation

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The causes of a reduced transfer factor in the presence of normal ventilatory function include:

  • interstitial lung disease
  • pulmonary vascular disease
  • anaemia


  • with respect to interstitial lung disease, the classic restrictive picture is of normal or even elevated FEV1/FVC ratio. However, absolute values for both FEV1 and FVC will decrease (1)


  1. Aaron SD et al. How accurate is spirometry at predicting restrictive pulmonary impairment? Chest. 1999 Mar;115(3):869-73.

Last reviewed 01/2018