Treatment depends upon the severity of the disease.
Replacement therapy is advised for patients with severe von Willebrand's disease or for moderate or major surgery.
Replacement involves cryoprecipitate infusion or a Factor VIII concentrate of high purity. Cryoprecipitate contains all molecular forms of vWF and is a more effective treatment for vWD than are factor VIII concentrates. After infusion of cryoprecipitate there is a delayed secondary rise of factor VIIIc levels.
Alternatives to blood-component therapy include topical thrombin, tranexamic acid and DDAVP, a synthetic vasopressin.
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