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Unconjugated hyperbilirubinaemia

Authoring team

Causes include:

  • increased bilirubin formation:
    • haemolysis
    • ineffective erythropoiesis:
      • megaloblastic anaemia
      • iron deficiency
      • haemoglobinopathies

  • failure of bilirubin uptake:
    • Gilbert's disease

  • failure of bilirubin conjugation:
    • neonatal jaundice
    • Crigler Najjar syndrome
    • drug inhibition e.g. chloramphenicol
    • extensive hepatocellular disease e.g. hepatitis, cirrhosis

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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