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Potassium sparing diuretics

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Potassium sparing diuretics inhibit sodium reabsorption late in the distal tubule and thus indirectly spare potassium excretion. They tend to cause bicarbonate loss, but not chloride.

  • often used in conjunction with other diuretics whose potencies are marred by their tendency to cause hypokalaemia. In particular, amiloride is most popular when prescribed with frusemide in co-amilofruse

  • spironolactone - there is evidence to show that spironolactone (e.g. 25mg per day) reduces mortality in congestive heart failure due to left ventricular systolic dysfunction

  • aldosterone antagonists such as spironolactone also have unique indications, such as the treatment of oedema resulting from cirrhosis of the liver, i.e. where aldosterone levels are high

Reference:

(1) Prescriber (2001), 12 (18), 49-61.

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