increased formation of uric acid

Last reviewed 01/2018

Mechanisms:

  • increased nucleic acid turnover:
    • lymphoma
    • psoriasis
    • haemolysis
    • myeloproliferative disease
    • muscle necrosis
    • enzyme deficiencies e.g. glucose-6-phosphatase

  • increased production:
    • Lesch-Nyhan syndrome
    • von Gierke's disease
    • high dietary purine intake e.g. sweetmeats, offal
    • fructose infusion