Hereditary elliptocytosis is an inherited autosomal dominant disorder in which red cells acquire elliptocytic shapes in the circulation as they are subjected to the normal circulatory shear stresses, for example passage through capillaries. It is relatively common, especially the mild form, with an incidence of 1 in 2500.
The predisposition to poikilocytosis results from various molecular abnormalities in the red cell membrane skeleton, most commonly:
Severe defects are associated with fragmentation, and occasionally, anaemia. Splenectomy is rarely required, but is very successful where indicated.
Different syndromes are recognised:
Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.