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Aetiology

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Nephrogenic diabetes insipidus is most commonly due to osmotic diuresis. Familial disease causes profound polyuria but is uncommon; it is sex linked recessive and thus more severe in boys

Acquired causes include:

  • osmotic:
    • diabetes mellitus
    • mannitol
    • post obstructive uropathy

  • chronic renal disease:
    • interstitial nephritis
    • polycystic kidneys
    • sickle cell anaemia
    • sarcoid
    • amyloid

  • metabolic:
    • hypercalcaemia
    • hypokalaemia

  • drugs:
    • lithium
    • demeclocycline
    • vitamin D
    • methoxyfluorane

  • solute washout from medulla due to prolonged polyuria of any cause

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