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Gemfibrozil and repaglinide

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

  • an interaction between gemfibrozil and repaglinide may occur when these drugs are administered concomitantly - in the situation the blood glucose-lowering effect of repaglinide may be markedly enhanced and prolonged. In light of this interaction, co-administration of gemfibrozil and repaglinide is contraindicated
  • any change in repaglinide pharmacokinetics as a result of co-administration of gemfibrozil is likely to via inhibition of cytochrome P450 2C8. Thus other inhibitors of this enzyme e.g. trimethoprim, may also, if co-administered, enhance of effect of repaglinide
  • it is not expected that other lipid-lowering agents will have a similar interaction with repaglinide

Reference:

  1. Current Problems in Pharmacovigilance (2003), 29, 6.

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