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Conditions and presentations when serological Coeliac disase screening should be considered

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

NICE suggest various presentations/conditions when serological testing should be considered but is not mandatory.

The list of conditions where coeliac disease serological screening should be considered includes:

  • metabolic/endocrine disorders:
    • Addison's disease
    • amenorrhoea
    • metabolic bone disease (such as rickets or osteomalacia)
    • microscopic colitis
    • reduced bone mineral density
  • autoimmune disorders:
    • autoimmune liver conditions
    • autoimmune myocarditis
    • Sjögren's syndrome
    • chronic thrombocytopenia purpura
  • chromosomal disorders:
    • Down's syndrome
    • Turner syndrome
  • presenting features that might prompt serological coeliac disease screening
    • low-trauma fracture
    • dental enamel defects
    • aphthous stomatitis (mouth ulcers)
    • persistent or unexplained constipation
    • persistently raised liver enzymes with unknown cause
    • polyneuropathy
    • recurrent miscarriage
    • depression or bipolar disorder
    • unexplained alopecia
    • unexplained subfertility
  • other conditions;
    • epilepsy
    • lymphoma
    • sarcoidosis
    • microscopic colitis

Reference:

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