trigger factors in ANCA associated vasculitis

Last reviewed 09/2022

  • the predominance of respiratory involvement, especially in GPA (Wegener's), led to investigation of the role of inhaled agents in the development of GPA

  • they observed no increase in inhaled particulates and fumes in GPA in general, but a significant increase in those with respiratory disease

  • a number of other possible trigger factors have also been reported, including silica, solvents, allergy and vaccination. A number of drugs have been implicated in the development of ANCA associated vasculitis (AAV)

  • patients with high-titre MPO antibodies are more likely to have taken hydralazine, propylthiouracil or allopurinol

  • leucotriene antagonists have been associated with development of EGPA (Churg Strauss), probably by unmasking pre-existing disease


  • 1) ARC Autumn 2012. Topical Reviews - ANCA-associated vasculitis; 1:1-12.