alternative options for women taking continuous combined oral HRT preparation containing 2mg of oestradiol

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Alternative options for women taking continuous combined oral HRT preparation containing 2mg of oestradiol

Women taking continuous combined oral HRT preparation containing 2mg of oestradiol, can consider the following:

  • Elleste Duet (trade mark) Conti 2mg oestradiol + 1mg norethisterone
  • Kliofem 2mg oestradiol + 1mg norethisterone acetate
  • Indivina 2mg oestradiol + 5mg medroxyprogesterone acetate
  • Or take oestrogen and progestogen separately:
    • Oral oestradiol 2mg plus either:
      • micronised progesterone: Utrogestan 100mg orally at night daily on continuous basis
      • Or Provera 5mg orally daily on continuous basis
      • Or Norethisterone 5mg orally daily on continuous basis (1mg would be sufficient for use in a continuous combined regimen but not available in stand-alone preparations)
        • Off license use of norethisterone in progestogen only contraceptive pills (e.g. Noriday 3 x tablets of 350 micrograms a day, will provide 1.05mg of norethisterone) may be considered as an equivalent alternative
      • Or Mirena IUS

Reference:

Last edited 05/2022 and last reviewed 05/2022

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