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Factor II deficiency

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Deficiencies of Factor's II, V and X are inherited as autosomal recessives. They occur rarely with reported incidences between 1 in 500 000 to 1 in 1 000 000, and result from the production of altered inactive forms of the relevant protein.

Laboratory tests show increased prothrombin and partial thromboplastic times - not corrected by administration of vitamin K; other tests are normal.

Diagnosis is by specific factor assay.

Acquired deficiencies of these diseases may result from:

  • antibodies to the appropriate Factor
  • lupus anticoagulants - e.g. systemic lupus erythematosus
  • systemic amyloidosis - amyloid fibrils bind to Factor X

Notes:

  • descriptive name for factor II is prothrombin
  • descriptive name for factor V is labile factor
  • descriptive name for factor X is Stuart-Power factor

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