autosomal dominant cerebellar ataxia
This is a heterogeneous group of adult-onset progressive ataxias which have an autosomal dominant mode of inheritance. There is often a widespread neuronal degeneration which resembles multiple system atrophy.
There are three main clinical groups:
- spinocerebellar ataxia type 1
- spinocerebellar ataxia type 2
- Machado-Joseph syndrome
- cerebellar cortical degeneration
Last reviewed 01/2018