octreotide in the treatment of oesophageal varices
- synthetic analogue of somatostatin
- longer half-life than somatostatin - therefore can be given by bolus injection
rather than continuous infusion
- a meta-analysis has collated trials published in English in which somatostatin
or octreotide were compared with other vasoactive drugs (vasopressin or terlipressin),
slerotherapy or balloon tamponade - the pooled results showed that somatostatin
and octreotide were more effective than the other vasoactive drugs in the
initial control of acute bleeding but neither appeared to reduce mortality
- evidence shows that the combination of somatostatin or octreotide and endoscopic therapy is more effective than either alone in controlling an initial oesophageal variceal bleed (2)
- 1) Gotzsche PC. Somatostatin or octreotide for acute bleeding oesophageal varices (Cochrane Review). In: The Cochrane Library, Issue 2, 2000. Oxford: Update Software.
- 2) Drug and Therapeutics Bulletin (2000), 38 (5), 37-40.
Last reviewed 01/2018