The main objective is to save as much of the limb as possible. With arterial disease, consider methods which improve poor blood supply, for example, direct arterial surgery, thrombolysis or sympathectomy.
The affected part should be kept dry by exposure and possibly, a fan. It should not be heated. Local pressure areas should be protected by padding to avoid the development of new patches of gangrene. Hard or desiccated skin should be removed if it assists the line of demarcation, the release of pus, or pain relief.
Amputation is indicated when the blood supply cannot be improved, the limb is crushed, or wet gangrene is spreading rapidly.
Other more specific actions may be taken directed towards the underlying aetiologic agent.
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