This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Go to /pro/cpd-dashboard page

This page is worth 0.05 CPD credits. CPD dashboard

Go to /account/subscription-details page

This page is worth 0.05 CPD credits. Upgrade to Pro

Selective noradrenaline reuptake inhibitors

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

An example of this class of antidepressant is roboxetine. Studies have shown that roboxetine is as effective as fluoxetine and tricyclic antidepressants. There have been claims that roboxetine has a greater effect on social functioning than other antidepressants.

Side effects include insomnia, increased sweating, tachycardia, impotence, vertigo, dry mouth and urinary retention. The frequency of side effects is low.

The frequency of suicide (0.3%) is lower than with imipramine, fluoxetine or placebo (1).

The published data on reboxetine suggests efficacy equivalent to traditional tricyclic antidepressants e.g. imipramine. The data suggesting a greater effect on social functioning requires independent confirmation.

The summary of product characteristics should be consulted before prescribing this drug.

Reference:

  • Drug and Therapeutics Bulletin (1998), 36 (11), 86-88.

Related pages

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.