Last reviewed 01/2018

Donepezil drug is indicated in the symptomatic treatment of mild to moderate Alzheimer's disease (AD).

  • acetylcholinesterase (AChE) inhibitors increase the concentration of acetylcholine at sites of neurotransmission
  • donepezil is a specific and reversible inhibitor of AChE, licensed in the UK at a dosage of 5 mg/day and 10 mg/day. It is licensed for the symptomatic treatment of people with mild to moderately severe Alzheimer's dementia

See NICE guidance for use in treatment of Alzheimer's disease.


  • donepezil improves cognitive outcomes in patients with Alzheimer's disease (AD). However evidence suggests that in patients with AD, donepezil has no significant beneficial effect for treating agitation, a common associated symptom (2)


  1. (1) NICE (November 2006).Donepezil, galantamine, rivastigmine (review) and memantine for the treatment of Alzheimer's disease
  2. (2) Howard RJ et al, Donepezil for the treatment of agitation in Alzheimer's disease. N Engl J Med. 2007 Oct 4; 357(14):1382-92.