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Pentagastrin test

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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The pentagastrin test is a test of basal and stimulated acid production by the parietal cells of the stomach. Pentagastrin is a synthetic peptide containing the five terminal amino acids of gastrin.

The pentagastrin test may be used in the diagnosis of:

  • Zollinger-Ellison syndrome:
    • basal acid secretion is high
    • little stimulation by pentagastrin

  • Achlorhydria:
    • basal acid secretion is low
    • little stimulation by pentagastrin

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