The trial enrolled 655 patients with adult-onset rheumatoid arthritis and compared the anti-inflammatory efficacy and the gastrointestinal side-effects of celecoxib versus diclofenac.
The trial had a double-blind, double-dummy, randomised, parellel design.
Anti-inflammatory effects were assessed every four weeks for 24 weeks. 430 patients received an upper GI endoscopy to assess the presence of ulceration.
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