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Methyl dopa

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Methyl dopa is a centrally-acting antihypertensive drug that is gradually declining in usage. It inhibits decarboxylation of dopa to dopamine. Therapy is associated with reduced concentrations of dopamine, 5 - hydroxytryptamine and noradrenaline in peripheral tissues and the CNS. This drug is associated with a reduction in renin levels.

Indications for the use of methyl dopa include:

  • hypertension, in conjunction with a diuretic
  • hypertensive crisis when an immediate effect is not necessary

Cautions/Contraindications:

  • history of depression
  • active liver disease
  • porphyria
  • phaeochromocytoma
  • increases the CNS toxicity of lithium

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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