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Treatment

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Management depends on staging.

Factors to be considered in planning therapy for vaginal cancer include:

  • stage and size of the lesion

  • proximity to radiosensitive organs or organs that preclude radical resection without unacceptable functional deficits (e.g., bladder, rectum, urethra)

  • ability to retain a functional vagina

  • presence or absence of the uterus

  • whether there has been previous pelvic radiation therapy

  • proximity of the vagina to the bladder or rectum limits surgical treatment options and increases short- and long-term surgical complications and functional deficits involving these organs

Stage I or II vaginal cancer

  • radiation or surgery or a combination of these treatments are standard treatment

Stages III and IVA vaginal cancer

  • radiation therapy is standard and includes external-beam radiation, alone or with brachytherapy. Regional lymph nodes are included in the radiation portal

Stage IVB or recurrent disease that cannot be managed with local treatments

  • current therapy is inadequate
  • no established anticancer drugs can be considered of proven clinical benefit, although patients are often treated with regimens used to treat cervical cancer

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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