This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Go to /pro/cpd-dashboard page

This page is worth 0.05 CPD credits. CPD dashboard

Go to /account/subscription-details page

This page is worth 0.05 CPD credits. Upgrade to Pro

Bullous pemphigoid

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

This acquired autoimmune blistering disorder is characterized by large, tense, subepidermal blisters on an erythematous base.

Autoantibodies (mainly IgG) targeting the components of the basement membrane can be detected (1).

Usually it is a disease of the elderly (2), rarely presenting before 50 years of age. In the UK, it is more common than pemphigus with an annual incidence of 1 per 10000.

Both men and women are affected equally (1). Pemphigoid may be associated with malignancy although this is disputed in recent studies (1).

It is the most common cutaneous subepidermal bullous autoimmune disorder (2). There is a high mortality rate associated with this disease (3).

Pemphigoid may be associated with malignancy although this is disputed in recent studies.

Click here for an example image of bullous pemphigoid

Drug-associated bullous pemphigoid (4):

  • drugs associated with development of bullous pemphigoid include:
    • antibiotics
    • beta-blockers
    • non-steroidal anti-inflammatory drugs (NSAIDs)
    • diuretics
    • anti-tumor necrosis factor (TNF)-alpha
    • dipeptidyl peptidase 4 inhibitors (DPP-4i)
    • immune checkpoint inhibitors targeting programmed cell death receptor 1 (PD-1) and its ligand (PD-L1)

High potency topical steroids and systemic steroids are the current mainstay of therapy (5).

Reference:


Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.