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Cholestasis

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Cholestasis is defined as failure of normal amounts of bile to reach the duodenum. The source of the interference may reside in the main bile ducts - extrahepatic cholestasis - or within the liver - intrahepatic cholestasis.

Morphologically, cholestasis is characterised by the accumulation of bile in liver cells and biliary passages; biochemically, by the retention of all substances normally excreted in the bile.

Presentation is usually with pruritus and the slow onset of jaundice.

The term "obstructive jaundice" usually refers to cholestasis of extra-hepatic origin.


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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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