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Propranolol in thyrotoxicosis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Propranolol blocks the peripheral adrenergic features of hyperthyroidism and partially inhibits the conversion of T4 to T3.

Regimen:

  • initially, 40 mg tds or qds PO - this is a high initial dose and reflects the increased metabolism of propranolol in hyperthyroidism

  • if there is no symptomatic relief within the first 24-48 hours, increase to 80 or 160 mg tds or qds

  • continue treatment until thyroid function has returned to normal via other therapies; then withdraw gradually

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