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Muir-Torre Syndrome

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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The Muir-Torre Syndrome describes a rare assembly of conditions:

  • sebaceous tumours
  • internal malignancies
  • keratoacanthomas - are not mandatory to the diagnosis

It is an autosomal dominant condition that has been linked to chromosome 2p. The sebaceous tumours are usually multiple and ranging in type from adenomata to carcinomata. These can co-exist with multiple and occasionally very large keratoacanthoma.

Internal malignancies associated with the condition are:

  • colonic cancer and polyposis coli
  • carcinoma of larynx
  • carcinoma of endometrium

Long-term retinoic acid has been used to treat this condition.


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