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The treatment of acute promyelocytic leukaemia comprises:

  • FFP and platelets to rectify the bleeding diathesis

  • daunorubicin and cytarabine are the preferred cytotoxic agents

  • ATRA during induction or maintenance improves outcome

  • after four courses of chemotherapy, look for evidence of minimal residual disease (by reverse transcription polymerase chain reaction search for PML/RAR in marrow aspirate); if present, proceed to bone marrow transplantation

Last reviewed 01/2018