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Interactions

Authoring team

ACE inhibitors interact with a number of drugs:

  • diuretics:
    • patients previously administered diuretics on a long-term basis have a high incidence of first-dose hypotension; this is minimised by reducing the diuretic dose for at least 24 hours before ACE inhibitors are instigated
  • lithium - ACE inhibitors raise the plasma concentration
  • antipsychotic drugs - ACE inhibitors precipitate postural hypotension
  • NSAID's reduce the antihypertensive effect of ACE inhibitors
  • cyclosporin - increases the risk of hyperkalaemia

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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