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Environmental causes of PCT

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Certain drugs and chemicals have been identified as causing the sporadic or symptomatic form of PCT:

  • alcohol - affects the activity of specific enzymes in the heme pathway
  • oestrogens - mechanism is poorly understood; based on the increased occurrence of PCT in women following the widespread usage of oestrogens as contraceptive agents and in men treated for prostatic carcinoma
  • hexachlorobenzene and other chlorinated phenols
  • iron - mechanism is complex; hepatic iron overload is found in nearly all cases of PCT

Other possible causes include (1):

  • viral infections:
    • hepatitis C virus
    • HIV
  • systemic disorders:
    • SLE
    • lymphoma

http://www.wmic.wales.nhs.uk/pdfs/bulletins/Porphyria%20bulletin%20July%202008.pdfReference:

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