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Pyrazinamide

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

This is the only bactericidal drug which is active against the intracellular forms of Mycobacterium tuberculosis. It is particularly useful in the treatment of tuberculous meningitis because of its good penetration of the blood- brain barrier.

Indications:

  • tuberculosis

Cautions:

  • gout
  • diabetes
  • beware interactions
  • impaired renal function

Contra-indications:

  • liver damage
  • porphyria

Side-effects:

  • nausea and vomiting
  • arthralgia
  • hepatomegaly
  • jaundice
  • hepatotoxicity including fever and anorexia
  • liver failure
  • sideroblastic anaemia
  • urticaria

Routes of administration:

  • oral

The summary of product characteristics should be consulted before prescribing this drug.


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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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