Last reviewed 08/2021

  • Graves' disease is the commonest cause of hyperthyroidism
  • females affected more than males in the ratio 5:1
  • peak incidence from 30-50 years of age
  • may affect 2 to 5% of all females at some time
  • association with HLA B8 and HLA DR3 in caucasians
  • there is some evidence that significant life events, for example, divorce or bereavement, may precipitate the development of Graves' disease
  • there is an association with smoking