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Bone diseases causing asymptomatic elevation of ALP

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The common diseases which may cause asymptomatic chronic elevation of alkaline phosphatase include:

  • Paget's disease
  • osteomalacia (vitamin D deficiency)

Note that vitamin D insufficiency may also be associated with an asymptomatic raised alkaline phosphatase level.

  • vitamin D deficiency
    • profiles of serum calcium, phosphate and alkaline phosphatase may sometimes be helpful in the diagnosis of vitamin D deficiency
      • note though that serum calcium and phosphate concentrations only fall in longstanding, symptomatic, vitamin D deficiency; there is an increase in levels of alkaline phosphatase (total and bone-specific) increase early in vitamin D deficiency
        • this is a non-specific finding, but may be helpful in diagnosing individuals with otherwise unexplained elevations in alkaline phosphatase

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