central retinal vein occlusion

Last edited 07/2021 and last reviewed 06/2023

This may present as a sudden painless loss of vision. It is less common than an occlusion of a branch vein and is less abrupt than a central retinal artery occlusion.

Elderly patients tend to be affected more severely since the venous obstruction is often compounded by a deficient retinal arterial supply - haemorrhagic retinopathy.

A meta-analysis suggested that DM is a risk factor for retinal vein occlusion (RVO) (1)

  • significant association between DM and the risk of RVO (OR = 1.68, 95% CI: 1.43-1.99)
  • subgroup analysis indicated that DM was significantly associated with central RVO (OR=1.98, 95% CI: 1.29-3.03, I2=67.9%), but not significantly associated with branch RVO (OR=1.22, 95% CI: 0.95-1.56, I2=64.1%)


  • Wang Y, Wu S, Wen F, Cao Q. Diabetes mellitus as a risk factor for retinal vein occlusion: A meta-analysis. Medicine (Baltimore). 2020;99(9):e19319.