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Pyruvate carboxylase

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Pyruvate carboxylase is a mitochondrial enzyme that converts pyruvate, bicarbonate ions and ATP into oxaloacetate, ADP and phosphate. It is used in gluconeogenesis as a stage in the interconversion of pyruvate to phosphoenolpyruvate. Also, it may provide oxaloacetate precursors for the tricarboxylic acid cycle at times of exercise.

It is inhibited by an increased concentration of intracellular ADP.


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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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