aetiology of D+ haemolytic uraemic syndrome

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Causes include:

  • E. coli, usually verotocytotoxin producing - VTEC - found in 75% of cases of D+ HUS. Verocytotoxin will kill endothelial cells. In the UK 75% of VTEC found in faecal specimens have the serotype O157:H7, screened for at public health laboratories.
  • shigella, usually flexeri which produces a toxin similar to that produced by VTEC
  • autoimmunity and endotoxin causing a neutrophil leukocytosis have also been implicated.

Last reviewed 08/2021

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