von Willebrand's disease (comparison with the features of Haemophilia A and Haemophilia B)

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Comparison between the clinical and laboratory features found in Haemophilia A, Haemophilia B and Von Willebrand's disease

 Haemophilia A Haemophilia BVon Willebrand's disease
Mode of inheritanceX-linkedX-linkedAutosomal Dominant (incomplete)
Main sites of Bleedingmuscle, joints, following trauma or post operationmuscle, joints, following trauma or post operationskin cuts, mucous membranes, following trauma and post operation
plateletsnormal platelet countnormal platelet countnormal platelet count
bleeding timenormal normalprolongation of bleeding time
prothrombin time normal normalnormal
Activated partial thromboplastin time (APTT)prolongedprolongedprolonged
von Willebrand's Factornormal normalreduced levels
factor VIII low levelsnormallow levels - vWF is the carrier molecule for factor VIII thus preventing it from premature destruction - this property explains the reduced factor VIII levels found in von Willebrands disease
factor IX normallow levelslow levels
ristocetin-induced platelet aggregationnormalnormal ristocetin fails to induce platelet aggregation in von Willebrand's patients because of lack of vWF:R - a cofactor for ristocetin

Last reviewed 01/2018