anti-histone antibody

Last reviewed 01/2018

  • autoantibodies to these proteins are found in SLE, especially in drug-induced SLE
    • characteristic pattersn of antibodies to different histone proteins can be elicited by certain drugs e.g. procainamide
    • anti-histone antibodies are found in about 95% of cases of drug-induced SLE in the absence of other autoantibodies
      • also found in about 50% of idiopathic lupus and far less frequently in systemic sclerosis, rheumatoid arthritis and mixed connective tissue disorders


  • (1) Sherley-Dale A. Serum autoantibodies and connective tissue disorders. Dermatology in Practice (April 2008); 16(1).