treatment of neurosyphilis

Last edited 07/2023 and last reviewed 08/2023

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The treatment of neurosyphilis is with procaine penicillin 900-1200 mg/day i.m. for 21 days.

Again, caution should be taken over the possiblity of a severe Jarisch-Herxheimer reaction for which prednisolone may be given.

CSF examination should be repeated after treatment and patients should be followed up for life.

Please check BNF and summary of product characteristics before prescribing drugs described.