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Treatment of transformed leukaemia

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Lymphoid blast crises respond best to standard ALL therapy - prednisolone or vincristine. A second chronic phase is achieved in 40-60%.

Myeloid blast crises are managed with AML therapy. A second chronic phase is achieved in 30% of patients.

Patients in a second chronic phase should receive:

  • AML or ALL maintenance therapy
  • craniospinal prophylaxis:
    • 6 intrathecal injections of methotrexate

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