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Corpus callosum signs

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Space-occupying lesions in the corpus callosum yield a distinctive clinical picture.

Mental symptoms are prominent and typically the first to be noticed. Common features are apathy, drowsiness and defect of memory; depression and anxiety may be present. Epileptic convulsions may occur.

An expanding lesion may lead to other symptoms depending upon the tissue affected:

  • midline lesions extending laterally to the central white matter may damage the corticospinal tracts
  • anterior lesions extending into the frontal lobes may cause a unilateral or bilateral grasp reflex
  • interruption of cortical callosal fibres linking related parts of the two hemispheres may produce apraxia

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