testosterone deficiency in the male

Last edited 05/2018 and last reviewed 04/2019

Testosterone deficiency in adult men

Based on the British Society for Sexual Medicine Guidelines on adult testosterone deficiency, with statements for UK practice1

Testosterone is the most important androgen in men. It regulates a number of vital processes in the body and is responsible for the development and maintenance of secondary male characteristics.2

When testosterone levels fall, patients can experience adverse physical and psychological effects, and a subsequent reduction in quality of life.3

Testosterone deficiency (TD) is defined as a clinical AND biochemical syndrome, associated with advancing age and comorbidities, characterised by a deficiency in serum testosterone PLUS relevant signs and symptoms.3,4


  • Professor Mike Kirby and Dr Jonny Coxon (May 2018)


  • 1. Hackett G, Kirby M, Edwards D et al. The British Society for Sexual Medicine guidelines on adult testosterone deficiency with statements for UK practice. J Sex Med 2017;14:1504-23.
  • 2. Dandona P, Rosenberg MT. A practical guide to male hypogonadism in the primary care setting. Int J Clin Pract 2010;64:682-696.
  • 3. Dean JD, McMahon CG, Guay AT, et al. The International Society for Sexual Medicine's process of care for the assessment and management of testosterone deficiency in adult men. J Sex Med 2015;12:1660-1686.
  • 4. Khera M, Adaikan G, Buvat J, et al. Diagnosis and Treatment of Testosterone Deficiency: Recommendations From the Fourth International Consultation for Sexual Medicine (ICSM 2015). J Sex Med 2016;13:1787-1804.