Unopposed oestrogen replacement therapy is associated with an increased incidence of:
- endometrial hyperplasia and endometrial carcinoma
- abnormal bleeding patterns
There is evidence of an increased risk of breast cancer if there has been more than 5 years of post-menopausal HRT.
There is a demonstrable increased risk of thrombosis (though very slight) with modern HRT formulations.
Last reviewed 09/2019