Last reviewed 07/2021

Atrial natriuretic peptide is released by myocytes in response to atrial stretch. There are a variety of forms; the originals isolated from the brain were smaller than the forms subsequently isolated from human heart.


  • reduction of ADH-induced water reabsorption in the collecting ducts
  • relaxation of renal arterioles
  • modulatory effects of the GFR
  • inhibition of aldosterone mediated sodium reabsorption in the distal tubule (natiuretic effect)

There is massive atrial natriuretic peptide activity in end stage renal failure and congestive cardiac failure.