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Pathology

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Although an increase in the myocardial oxygen demand or a decrease in the oxygen-carrying capacity of the blood may cause ischaemic heart disease, nevertheless in over 90% of cases the cause is coronary artery disease.

There are five main contributors to the pathogenesis of coronary artery disease:

  • atherosclerosis of the coronary arteries
  • platelet aggregation
  • coronary vasospasm
  • non-atherosclerotic coronary artery disease
  • haemodynamic derangements

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