SOLVD - prevention arm

Last reviewed 01/2018

This multicentre, randomised, double-blind, placebo-controlled trial enrolled 4228 patients with reduced left ventricular function (ejection fraction <35%) but without symptomatic heart failure.

The addition of enalapril to the conventional heart failure treatment resulted in a significant 37% decrease in the incidence of heart failure.


  • SOLVD Investigators. (1992). N Engl J Med. 327, 685-691.