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Investigations

Authoring team

Radiology:

  • plain abdominal radiology - typical microcalcification of tumour noted in 50% of cases
  • chest radiology - for evidence of metastases
  • abdominal CT with intravenous contrast - helps to distinguish neuroblastoma from Wilm's tumour
  • chest CT should be performed to look for metastases
  • isotope bone scan for metastases

Biochemistry:

  • urinary excretion of catecholamine metabolites - levels of vanillylmandelic acid, homovanillic acid raised in 75% of cases
  • the ratio of a spot VMA concentration to urinary creatinine may be helpful where a 24 hour collection is impractical

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