This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages without signing in

Paget's disease of bone

Authoring team

Paget's disease is the second most common metabolic bone disease after osteoporosis and is the commonest cause of bone dysplasia.

  • it is characterised by one or more areas of aggressive osteoclast-mediated bone resorption followed by imperfect osteoblast-mediated bone repair (1)

Involvement of the disease is monostotic in 15% of cases and polyostotic in the remainder.

  • can affect any bone but frequently the axial skeleton is involved. The usual sites include
    • pelvis (70%)
    • femur (55%)
    • lumbar spine (53%)
    • skull (42%)
    • tibia (32%) (2)
  • when long bones are affected they may become bowed
  • thickening of the skull may lead to compression of cranial nerves with consequent palsies.

Many cases of Paget's disease are asymptomatic.

Reference:

Related pages

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.