pathogenesis of atopic asthma

Last reviewed 04/2018

Atopic asthma is the result of airways inflammation caused by exposure to an environmental allergen.

Patients with asthma have an exuberant Th2-mediated IgE humoural immune response.

IgE binds to bronchial mast cells via the FcERI (high affinity receptor) resulting in degranulation and the release of pro-inflammatory mediators.

There are two phases of inflammation:

  • acute phase
  • delayed phase

The results of inflammation are:

  • bronchial hyper-reactivity
  • symptoms of cough, wheeze and chest tightness
  • signs of variable polyphonic wheezes